Henderson County is a county in the U.S. state of Kentucky. The county is located in western Kentucky on the Ohio River across from Evansville, Indiana. As of the 2020 census, the population was 44,793. Its county seat is Henderson.

Area: 466 mi²

Founded: 1799

Population: 44,329 (2021)

County seat: Henderson

Cities: Corydon, Robards, Henderson